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Midodrine is a vasopressor hypotension medication. The Food and Drug Administration (FDA) has approved midodrine in the United States in 1996 for the treatment of dysautonomia and orthostatic hypotension.

Available Midodrine brands of low blood pressure medications: Amatine, ProAmatine, Gutron.


How does midodrine work to raise low blood pressure? Midodrine works by stimulating nerve endings in blood vessels, causing the blood vessels to tighten. As a result, blood pressure increases.

Who can use midodrines medications? It is useful to the people with orthostatic hypotension (symptoms of low blood pressure when standing).  If low blood pressure symptoms severely affect your daily activities, which are not manageable with other treatments such as support stocking. In particular, it is for low blood pressure individuals causing by kidney dialysis and for children with an infection. It is also for a treatment for chronic fatigue syndrome and hepato pulmonary syndrome.

You should not use Midodrine if you are having severe organic heart disease, acute renal disease, urinary retention, or supine hypertension.

How do you take midodrine drugs? Take this medication with or without food, usually three times daily with an at least four-hour gaps. If you are going to lie down or before bedtime, avoid taking this medication.

What can expect from midodrine drug medication? It prevents expansion of blood vessels and thus raises your blood pressure, particularly in case of orthostatic hypotension (low blood pressure when standing up).

What are some possible side effects of midodrine drugs? Side effects are tingling/itching skin, rash, chills, slow heartbeat, heart pounding, unusual-chest-sensation, fainting, urinary problems, ear blow sensation, headache, blurred vision, and vision problems.

Possible drug interaction with midodrine

Midodrine may interact with following medication, so try avoid taking it if possible:

  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine),
  • Adrenaline-like drugs (e.g., ephedrine, phenylephrine, pseudoephedrine),
  • Alpha blockers (e.g., doxazosin, prazosin, terazosin),
  • Beta-blockers (e.g., atenolol, metoprolol),
  • Digoxin,
  • Ergot alkaloids (e.g., dihydroergotamine, ergotamine),
  • NSAIDs such as ibuprofen, naproxen: because they may contain ingredients that could increase your blood pressure. 

If you are panic about medication’s side effects, you can alternatively manage with low blood pressure home remedies. Additionally, you can also consider trying low blood-pressure natural treatments.

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